Ischemic heart disease and its risk factors in patients with diabetic foot ulcers: A systematic review and meta-analysis

Fathmath N M Waheed; Venkat N Vangaveti; Usman H Malabu

doi:10.1016/j.dsx.2022.102414

Ischemic heart disease and its risk factors in patients with diabetic foot ulcers: A systematic review and meta-analysis

Diabetes Metab Syndr. 2022 Feb;16(2):102414. doi: 10.1016/j.dsx.2022.102414. Epub 2022 Jan 25.

Authors

Fathmath N M Waheed¹, Venkat N Vangaveti¹, Usman H Malabu²

Affiliations

¹ Translational Research in Endocrinology and Diabetes, College of Medicine and Dentistry, James Cook University, Australia.
² Translational Research in Endocrinology and Diabetes, College of Medicine and Dentistry, James Cook University, Australia; Department of Diabetes and Endocrinology, Townsville University Hospital, Australia. Electronic address: usman.malabu@jcu.edu.au.

PMID: 35104751
DOI: 10.1016/j.dsx.2022.102414

Abstract

Aims: There is limited literature on IHD in DFU patients. This review aimed to determine the prevalence of and risk factors of IHD in patients with DFUs.

Methods: Seven electronic databases were searched from inception to April 2021.

Results: The prevalence of IHD in DFU patients ranged from 6.83% to 60.61% with a pooled mean of 25.85% (95% CI, 24.28%-27.32%). Several risk factors were identified including hypertension, male gender, smoking, and peripheral vascular disease.

Conclusion: We identified multiple risk factors for IHD requiring early interventions to increase long-term quality of life for patients with DFUs.

Keywords: Diabetic foot ulcer; Ischemic heart disease; Prevalence; Risk factors.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Diabetes Mellitus*
Diabetic Foot* / epidemiology
Diabetic Foot* / etiology
Humans
Male
Myocardial Ischemia*
Peripheral Vascular Diseases*
Quality of Life
Risk Factors