Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population

Circ Genom Precis Med. 2022 Feb;15(1):e003574. doi: 10.1161/CIRCGEN.121.003574. Epub 2022 Feb 1.

Christian Paludan-Müller^{1

2

3}, Simon Larsen^{1

2}, Gustav Ahlberg^{1

2

3}, Laura Andreasen^{1

2}, Laia M Monfort^{1

2

3}, Jesper H Svendsen^{1

3}, Thomas Jespersen², Henning Bundgaard^{4

3}, Jørgen K Kanters⁵, Morten S Olesen^{1

2}

¹ Laboratory for Molecular Cardiology (C.P.-M., S.L., G.A., L.A., L.M.M., J.H.S., M.S.O.), Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Denmark.
² Department of Biomedical Sciences (C.P.-M., S.L., G.A., L.A., L.M.M., T.J., M.S.O.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
³ Department of Clinical Medicine (C.P.-M., G.A., L.M.M., J.H.S., H.B.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
⁴ The Unit for Inherited Cardiac Diseases (H.B.), Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Denmark.
⁵ Laboratory of Experimental Cardiology, Department of Biomedical Sciences (J.K.K.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

No abstract available

Keywords: atrial fibrillation; bundle-branch block; exome; exon; genetic variation.

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