Dynamic Transformation of DNA Nanostructures inside Living Cells

Xiaohui Ding; Zhaoyue Lv; Nuo Xu; Feng Li; Dayong Yang

doi:10.1002/cplu.202100519

Dynamic Transformation of DNA Nanostructures inside Living Cells

Chempluschem. 2022 Feb;87(2):e202100519. doi: 10.1002/cplu.202100519.

Authors

Xiaohui Ding¹, Zhaoyue Lv¹, Nuo Xu¹, Feng Li¹, Dayong Yang¹

Affiliation

¹ Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, P. R. China.

PMID: 35103422
DOI: 10.1002/cplu.202100519

Abstract

DNA nanostructures, that show sequence programmable responsiveness to intracellular signals, have been explored as potential candidates of artificial dynamic functional structures in living cells. Recently, we developed a series of intracellular signals responding DNA nanostructures in living cells to perform a special mission. In this review, the developed DNA nanostructures and their dynamic transformation properties are summarized and discussed. The DNA nanostructures are generally categorized into DNA-inorganic nanomaterials and DNA-organic nanomaterials depending on the composition. At the end of this review, the challenges and prospects on instructing dynamic DNA nanostructures in living cells are discussed. We believe that this review will contribute to the further development of stimuli-responsive nanomaterials, which is of great potential in biomedical applications.

Keywords: DNA nanotechnology; biomaterials; dynamic assembly; stimulus-responsiveness.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA / chemistry
Nanostructures* / chemistry

Substances

DNA

Abstract

Publication types

MeSH terms

Substances

Grants and funding