Insight on structural modification, biological activity, structure-activity relationship of PPD-type ginsenoside derivatives

Yangliu Tong; Xiaoping Song; Yanxin Zhang; Ying Xu; Qingchao Liu

doi:10.1016/j.fitote.2022.105135

Insight on structural modification, biological activity, structure-activity relationship of PPD-type ginsenoside derivatives

Fitoterapia. 2022 Apr:158:105135. doi: 10.1016/j.fitote.2022.105135. Epub 2022 Jan 31.

Authors

Yangliu Tong¹, Xiaoping Song², Yanxin Zhang¹, Ying Xu¹, Qingchao Liu³

Affiliations

¹ College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, China.
² College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Biotech. & Biomed. Research Institute, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, China. Electronic address: 20185322@nwu.edu.cn.
³ College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, China. Electronic address: liuqc21@nwu.edu.cn.

PMID: 35101587
DOI: 10.1016/j.fitote.2022.105135

Abstract

Ginsenosides, characterized by triterpenoid, are one of the active components of ginseng. Among them, PPD-type ginsenosides have potent and diverse pharmacological activities, while the effective applications and clinical studies are limited by the poor stability, water solubility and oral bioavailability. In this review, we have attempted to demonstrate the structural-activity relationship of chemical modifications on the dammarane-type skeleton and the C-17 side chain, noting that certain structurally modified derivatives exhibit satisfactory pharmacological activity. This review will provide ideas for the design and synthesis of novel PPD derivatives, and valuable help for the further study of PPD derivatives to make it realize clinical application.

Keywords: Biological activity; Derivatives; PPD-type ginsenosides; Structural modification; Structure-activity relationship.

Publication types

Review

MeSH terms

Ginsenosides* / pharmacology
Molecular Structure
Panax* / chemistry
Structure-Activity Relationship

Substances

Ginsenosides