Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice through Activating TNF-α Pathway

Mov Disord. 2022 Mar;37(3):664-665. doi: 10.1002/mds.28948. Epub 2022 Jan 31.

Authors

Pascal Derkinderen^{1

2}, Adrien de Guilhem de Lataillade^{1

2}, Michel Neunlist¹, Malvyne Rolli-Derkinderen¹

Affiliations

¹ Université de Nantes, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.
² Department of Neurology, CHU Nantes, Nantes, France.

PMID: 35100471
DOI: 10.1002/mds.28948

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Colitis*
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / metabolism
Mice
Parkinsonian Disorders* / genetics
Parkinsonian Disorders* / metabolism
Tumor Necrosis Factor-alpha / genetics

Substances

Tumor Necrosis Factor-alpha
LRRK2 protein, human
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2