Solid papillary carcinoma of the breast

Toyaja Jadhav; Shashi Shekhar Prasad; Bhupesh Guleria; Manvir Singh Tevatia; Prerna Guleria

doi:10.4322/acr.2021.352

Solid papillary carcinoma of the breast

Autops Case Rep. 2022 Jan 13:12:e2021352. doi: 10.4322/acr.2021.352. eCollection 2022.

Authors

Toyaja Jadhav¹, Shashi Shekhar Prasad¹, Bhupesh Guleria², Manvir Singh Tevatia³, Prerna Guleria¹

Affiliations

¹ Command Hospital (Southern Command), Department of Pathology, Pune, Maharashtra, India.
² Command Hospital (Southern Command), Department of Medical Oncology, Malignant Diseases Treatment Center, Pune, Maharashtra, India.
³ Command Hospital (Southern Command), Pune, Maharashtra, India.

Abstract

Solid Papillary Carcinoma (SPC) of the breast is a rare tumor with an incidence of less than 1%, mainly affecting elderly females. It is morphologically characterized by well-defined nodules with low-grade nuclear features associated with fibrovascular cores and shows neuroendocrine differentiation. SPC can be in-situ or invasive but has a favorable prognosis. It is a morphological mimicker of some pre-malignant conditions leading to its frequent misdiagnosis. An appropriate immunohistochemical (IHC) panel workup helps in distinguishing this tumor from its various morphological mimics. In this report, we present one such case of SPC with a small focus of invasion, reviewing the literature.

Keywords: Breast Neoplasms; Carcinoma; Carcinoma, Papillary; Unilateral Breast Neoplasms.

Publication types

Review