Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible

Kenji Yamagata; Naomi Ishibashi-Kanno; Ryota Matsuoka; Fumihiko Uchida; Satoshi Fukuzawa; Hiroki Bukawa

doi:10.1155/2022/9321728

Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible

Case Rep Dent. 2022 Jan 21:2022:9321728. doi: 10.1155/2022/9321728. eCollection 2022.

Authors

Kenji Yamagata¹, Naomi Ishibashi-Kanno¹, Ryota Matsuoka², Fumihiko Uchida¹, Satoshi Fukuzawa¹, Hiroki Bukawa¹

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan.
² Department of Diagnostic Pathology, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan.

Abstract

We present the first, to our knowledge, case of a dedifferentiated low-grade central osteosarcoma (LCOS) of the mandible. A 48-year-old Japanese woman underwent enucleation under general anesthesia after a diagnosis of ossifying fibroma. At the second recurrence, the pathological diagnosis after biopsy was of sarcoma with MDM2(+) and CDK4(+) immunohistochemical staining results. Hemimandibulotomy, supraomohyoid neck dissection, and free-flap reconstruction with a rectus abdominal flap were performed. A retrospective reevaluation of the first specimen with additional immunohistochemical staining for MDM2 and CDK4 yielded a final diagnosis of dedifferentiated LCOS. The patient showed no recurrence or lung metastasis 3 years after the final surgery.

Publication types

Case Reports