Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. It has a high degree of malignancy and a poor prognosis in developing countries. The doctor manually explained that magnetic resonance imaging (MRI) suffers from subjectivity and fatigue limitations. In addition, the structure, shape, and position of osteosarcoma are complicated, and there is a lot of noise in MRI images. Directly inputting the original data set into the automatic segmentation system will bring noise and cause the model's segmentation accuracy to decrease. Therefore, this paper proposes an osteosarcoma MRI image segmentation system based on a deep convolution neural network, which solves the overfitting problem caused by noisy data and improves the generalization performance of the model. Firstly, we use Mean Teacher to optimize the data set. The noise data is put into the second round of training of the model to improve the robustness of the model. Then, we segment the image using a deep separable U-shaped network (SepUNet) and conditional random field (CRF). SepUnet can segment lesion regions of different sizes at multiple scales; CRF further optimizes the boundary. Finally, this article calculates the area of the tumor area, which provides a more intuitive reference for assisting doctors in diagnosis. More than 80000 MRI images of osteosarcoma from three hospitals in China were tested. The results show that the proposed method guarantees the balance of speed, accuracy, and cost under the premise of improving accuracy.
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