AGA Clinical Practice Update on Approach to the Use of Noninvasive Colorectal Cancer Screening Options: Commentary

Gastroenterology. 2022 Mar;162(3):952-956. doi: 10.1053/j.gastro.2021.09.075. Epub 2022 Jan 28.

Abstract

The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update Commentary is to review the available evidence and provide expert advice regarding the approach to using noninvasive colorectal cancer (CRC) screening options, including evidence for their effectiveness, selection of individuals for whom these tests are appropriate, implications of a positive non-colonoscopy screening test, and opportunities to enhance the quality of noninvasive CRC screening programs. This Clinical Practice Update was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Gastroenterology. This expert commentary reflects recently published studies in this field, as well as the experiences of the authors who are gastroenterologists with high-level expertise in CRC screening and prevention.

Keywords: Colorectal Cancer Screening; Fecal Immunochemical Testing; Multi-Target Stool DNA Testing.

Publication types

  • Review

MeSH terms

  • Adenoma / blood
  • Adenoma / diagnosis*
  • Adenoma / urine
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / urine
  • DNA / analysis*
  • DNA / blood
  • DNA Methylation
  • Early Detection of Cancer / methods*
  • Feces / chemistry
  • Humans
  • Occult Blood*
  • Patient Selection
  • Practice Guidelines as Topic
  • Risk Assessment
  • Septins / genetics

Substances

  • DNA
  • SEPTIN9 protein, human
  • Septins