Microfluidics based point-of-care for disease diagnostics

Gargi Bhattacharjee; Rupesh Maurya; Khalid J Alzahrani; Nisarg Gohil; Navya L Lam; Vijai Singh

doi:10.1016/bs.pmbts.2021.07.024

Microfluidics based point-of-care for disease diagnostics

Prog Mol Biol Transl Sci. 2022;187(1):241-248. doi: 10.1016/bs.pmbts.2021.07.024. Epub 2021 Aug 12.

Authors

Gargi Bhattacharjee¹, Rupesh Maurya¹, Khalid J Alzahrani², Nisarg Gohil¹, Navya L Lam³, Vijai Singh⁴

Affiliations

¹ Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India.
² Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
³ The J. David Gladstone Institutes, San Francisco, CA, United States.
⁴ Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India. Electronic address: vijaisingh15@gmail.com.

PMID: 35094776
DOI: 10.1016/bs.pmbts.2021.07.024

Abstract

Microfluidics platform is widely used for several basic biological to advanced biotechnological applications. It reduces the expenditure of reagent consumption by readily reducing the volume of the reaction system. It is being used for early diagnosis of diseases, detection of pathogens, cancer markers, high-throughput screening and many such applications. Currently, microfluidics and lab-on-chip is integrated together with sample preparation, extraction, analysis and detection of biomarkers for disease diagnosis. This technology offers low-cost, rapid, sensitive and paper-based lateral flow mode of detection which is user-friendly and scalable. In this chapter, we highlight recent developments in microfluidics platform for disease diagnosis.

Keywords: Biomarkers; Detection; Diagnostic; Lab-on-chip; Microfluidics; Point-of-care.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
High-Throughput Screening Assays
Humans
Microfluidics*
Oligonucleotide Array Sequence Analysis
Point-of-Care Systems*

Substances

Biomarkers