MUC1 deficiency induces the nasal epithelial barrier dysfunction via RBFOX3 shortage augment ubiquitin-proteasomal degradation in allergic rhinitis pathogenesis

Chunyi Zhang; Yiyan Wang; Wenjing Liao; Tianhao Liang; Weixing Liu; Junyang Xie; Xiaofen Wang; Pingchang Yang; Wenju Lu; Xiaowen Zhang

doi:10.1111/all.15235

MUC1 deficiency induces the nasal epithelial barrier dysfunction via RBFOX3 shortage augment ubiquitin-proteasomal degradation in allergic rhinitis pathogenesis

Allergy. 2022 May;77(5):1596-1599. doi: 10.1111/all.15235. Epub 2022 Feb 11.

Authors

Chunyi Zhang^{1

2

3

4}, Yiyan Wang^{1

2

3}, Wenjing Liao^{1

2

3

4}, Tianhao Liang^{1

2

3}, Weixing Liu^{1

2

3}, Junyang Xie^{1

2

3}, Xiaofen Wang^{1

2

3}, Pingchang Yang⁵, Wenju Lu⁴, Xiaowen Zhang^{1

2

3

4}

Affiliations

¹ State Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head & Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
² Innovation and transformation platform of upper airway disease in Guangdong province, Guangzhou, China.
³ Department of Allergy and Clinical Immunology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
⁴ State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁵ Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.

PMID: 35094408
DOI: 10.1111/all.15235

No abstract available

Keywords: ENT (rhinitis, sinusitis, nasal polyps...); allergy treatment; epithelium; rhinitis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Humans
Mucin-1
Nasal Mucosa
Nasal Polyps*
Rhinitis*
Rhinitis, Allergic*
Sinusitis*
Ubiquitin

Substances

MUC1 protein, human
Mucin-1
Ubiquitin