Biodegradable Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering

Aneela Anwar; Daniel Jerome Petrino Jr; Nicole Van Alstine; Xiaojun Yu

doi:10.1007/978-1-0716-1811-0_36

Biodegradable Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering

Methods Mol Biol. 2022:2394:693-711. doi: 10.1007/978-1-0716-1811-0_36.

Authors

Aneela Anwar^{1

2}, Daniel Jerome Petrino Jr¹, Nicole Van Alstine¹, Xiaojun Yu³

Affiliations

¹ Biomedical Engineering Department, Stevens Institute of Technology, Hoboken, NJ, USA.
² Department of Basic Sciences and Humanities, University of Engineering and Technology, Lahore, Pakistan.
³ Biomedical Engineering Department, Stevens Institute of Technology, Hoboken, NJ, USA. xyu@stevens.edu.

PMID: 35094353
DOI: 10.1007/978-1-0716-1811-0_36

Abstract

Biodegradable nanocomposite scaffolds have been used for bone regeneration by serving as provisional template with optimal mechanical and biological properties analogous to native extracellular matrix (ECM). Their unique biomimicking structures aid in cell adhesion, differentiation, and proliferation with similar characteristics of the cells' ECM. Researchers are currently faced with a roadblock on ways to develop emerging process techniques to make biodegradable nanocomposite scaffolds and imitate these in exact synthetic ECM environments. This chapter particularly focuses on the technique of electrospinning for fabricating synthetic bone substitute materials for promoting bone repair and regeneration.

Keywords: Biodegradation; Bone; Collector; Electrospinning; Nanocomposite; Nanofiber; Polymer; Regeneration; Scaffold; Tissue.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bone and Bones
Extracellular Matrix / chemistry
Nanofibers* / chemistry
Tissue Engineering* / methods
Tissue Scaffolds / chemistry

Grants and funding

R01 EB020640/EB/NIBIB NIH HHS/United States