Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

Chem Commun (Camb). 2022 Feb 17;58(15):2516-2519. doi: 10.1039/d1cc06663c.

Abstract

The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}-{HSQC}-{TOCSY}, where magnetization of non-13C attached protons effectively is channeled from the TOCSY spectrum toward primarily the least sensitive spectrum of HMBC. The experiment is expected to find its place as a full-package NMR method for metabolomics, carbohydrates, peptides and small-molecules in general.

MeSH terms

  • Carbon Isotopes
  • Magnetic Resonance Spectroscopy
  • Nitric Oxide / analysis*

Substances

  • Carbon Isotopes
  • Nitric Oxide
  • Carbon-13