Retrospective Cohort Study of the Incidence and Outcomes of Jarisch-Herxheimer Reactions After Treatment of Infectious Syphilis in Late Pregnancy

Sex Transm Dis. 2022 Oct 1;49(10):e107-e109. doi: 10.1097/OLQ.0000000000001610. Epub 2022 Jan 29.

Abstract

Of 39 pregnant women at ≥20 weeks' gestation treated with benzathine penicillin G for infectious syphilis, we identified only 2 mild Jarisch-Herxheimer reactions. There were no immediate fetal sequelae. Data from our study do not support the recommendation for routine admission for the treatment of infectious syphilis in late pregnancy.

MeSH terms

  • Female
  • Humans
  • Incidence
  • Penicillin G Benzathine / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Infectious* / drug therapy
  • Pregnancy Complications, Infectious* / epidemiology
  • Retrospective Studies
  • Syphilis* / drug therapy
  • Syphilis* / epidemiology

Substances

  • Penicillin G Benzathine