Multivariate statistical analysis of L-dopa esters as potential anti-parkinsonian prodrugs

H Van de Waterbeemd; B Testa; C Marrel; D R Cooper; P Jenner; C D Marsden

Multivariate statistical analysis of L-dopa esters as potential anti-parkinsonian prodrugs

Drug Des Deliv. 1987 Dec;2(2):135-43.

Authors

H Van de Waterbeemd¹, B Testa, C Marrel, D R Cooper, P Jenner, C D Marsden

Affiliation

¹ School of Pharmacy, University of Lausanne, Switzerland.

PMID: 3509346

Abstract

This paper reports a QSAR study of thirteen L-DOPA esters previously synthesised and examined for their physicochemical, biochemical and behavioural properties. Multivariate statistical analysis (principal component analysis, cluster analysis, simple and multiple linear regression) reveals favourable and unfavourable structural features of L-DOPA prodrugs. Some of the many biochemical and behavioural activities investigated are shown to be redundant. These indications may contribute to the design of novel L-DOPA prodrugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analysis of Variance
Antiparkinson Agents / chemical synthesis*
Levodopa / analogs & derivatives*
Levodopa / chemical synthesis
Prodrugs / chemical synthesis*
Regression Analysis
Structure-Activity Relationship

Substances

Antiparkinson Agents
Prodrugs
Levodopa