Host miRNAs-microbiota interactions in gastric cancer

Yan Yang; Yingying Huang; Wu Lin; Jin Liu; Xiangliu Chen; Chuanzhi Chen; Xiongfei Yu; Lisong Teng

doi:10.1186/s12967-022-03264-3

Host miRNAs-microbiota interactions in gastric cancer

J Transl Med. 2022 Jan 29;20(1):52. doi: 10.1186/s12967-022-03264-3.

Authors

Yan Yang^{1

2}, Yingying Huang^{1

2}, Wu Lin^{1

2}, Jin Liu^{1

2}, Xiangliu Chen^{1

2}, Chuanzhi Chen^{1

2}, Xiongfei Yu¹, Lisong Teng³

Affiliations

¹ Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
² Clinical Research Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
³ Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China. lsteng@zju.edu.cn.

Abstract

It is widely acknowledged that gastric cancer seriously affects the quality of life and survival of patients. The correlation between the microbiota and gastric cancer has attracted extensive attention in recent years, nonetheless the specific mechanism of its impact on gastric cancer remain largely unclear. Recent studies have shown that in addition to its role in the host's inflammatory and immune response, the microbiota can also affect the occurrence and development of gastric cancer by affecting the expression of miRNAs. This paper brings together all currently available data on miRNAs, microbiota and gastric cancer, and preliminarily describes the relationship among them.

Keywords: Gastric cancer; Metabolic interactions; Microbiota; Microenvironment; miRNAs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Host Microbial Interactions
Humans
MicroRNAs* / genetics
Microbiota*
Quality of Life
Stomach Neoplasms* / genetics

Substances

MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding