Using scaffolds as drug delivery systems to treat bone tumor

Caifeng Wang; Zijiu Ma; Kemeng Yuan; Tianjiao Ji

doi:10.1088/1361-6528/ac5017

Using scaffolds as drug delivery systems to treat bone tumor

Nanotechnology. 2022 Mar 4;33(21). doi: 10.1088/1361-6528/ac5017.

Authors

Caifeng Wang^{1

2}, Zijiu Ma³, Kemeng Yuan^{1

2}, Tianjiao Ji^{1

2}

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, People's Republic of China.
² Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
³ College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

PMID: 35092950
DOI: 10.1088/1361-6528/ac5017

Abstract

Surgery is the principal strategy to treat osteosarcoma and other types of bone tumors, but it causes bone defects that cannot be healed spontaneously. After surgery, patients still need to receive radiotherapy and/or chemotherapy to prevent tumor recurrence and metastasis, which leads to systemic side effects. Bone scaffolds exhibit the potentials to load cargos (drugs or growth factors) and act as drug delivery systems (DDSs) in the osteosarcoma postoperative treatment. This review introduces current types of bone scaffolds and highlights representative works using scaffolds as DDSs to treat osteosarcomas. Challenges and perspectives in the scaffold-based DDSs are also discussed. This review may provide references to develop effective and safe strategies for osteosarcoma postoperative treatment.

Keywords: drug delivery systems; osteosarcoma; postoperative treatment; scaffolds.

Publication types

Review

MeSH terms

Animals
Bone Neoplasms / drug therapy*
Bone Regeneration / drug effects
Bone and Bones / drug effects
Drug Delivery Systems / methods*
Humans
Tissue Scaffolds / chemistry*