Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

Brandon J Aubrey; Margs S Brennan; Sarah T Diepstraten; Zilu Wang; Catherine Chang; Marco J Herold; Andreas Strasser; Gemma L Kelly

doi:10.1038/s41418-022-00946-9

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

Cell Death Differ. 2022 May;29(5):1074-1076. doi: 10.1038/s41418-022-00946-9. Epub 2022 Jan 28.

Authors

Brandon J Aubrey^{1

2

3}, Margs S Brennan^{1

2

4}, Sarah T Diepstraten^{1

2}, Zilu Wang^{1

2}, Catherine Chang¹, Marco J Herold^{1

2}, Andreas Strasser^#^{5

6}, Gemma L Kelly^#^{7

8}

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
² Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
³ Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
⁴ Department of Medicine Huddinge, Centre for Haematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
⁵ The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia. strasser@wehi.edu.au.
⁶ Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia. strasser@wehi.edu.au.
⁷ The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia. gkelly@wehi.edu.au.
⁸ Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia. gkelly@wehi.edu.au.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Lymphocytes / pathology
Lymphoma*
Lymphoma, Mantle-Cell* / pathology
Myeloid Cell Leukemia Sequence 1 Protein
Tumor Suppressor Protein p53 / genetics

Substances

Myeloid Cell Leukemia Sequence 1 Protein
Tumor Suppressor Protein p53