Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques

Jiang-Feng Liu; Ya-Nan Zhou; Shuai-Yao Lu; Ye-Hong Yang; Song-Feng Wu; De-Pei Liu; Xiao-Zhong Peng; Jun-Tao Yang

doi:10.1038/s41392-022-00882-7

Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques

Signal Transduct Target Ther. 2022 Jan 28;7(1):27. doi: 10.1038/s41392-022-00882-7.

Authors

Jiang-Feng Liu^#¹, Ya-Nan Zhou^#^{2

3}, Shuai-Yao Lu^#^{4

5}, Ye-Hong Yang¹, Song-Feng Wu⁶, De-Pei Liu⁷, Xiao-Zhong Peng^{8

9}, Jun-Tao Yang¹⁰

Affiliations

¹ State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.
² National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
³ State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
⁴ National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China. lushuaiyao-km@163.com.
⁵ State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. lushuaiyao-km@163.com.
⁶ State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Institute of Lifeomics, Beijing, 102206, China.
⁷ State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. liudp@pumc.edu.cn.
⁸ National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China. pengxiaozhong@pumc.edu.cn.
⁹ State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. pengxiaozhong@pumc.edu.cn.
¹⁰ State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China. yangjt@pumc.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
COVID-19 / genetics*
COVID-19 / immunology
COVID-19 / pathology
COVID-19 / virology
Gene Expression Regulation
Host-Pathogen Interactions / genetics*
Host-Pathogen Interactions / immunology
Humans
Liver / immunology
Liver / pathology
Liver / virology
Lung / immunology
Lung / pathology
Lung / virology
Macaca mulatta / genetics
Macaca mulatta / immunology
Macaca mulatta / virology*
Metabolic Networks and Pathways / genetics
Metabolic Networks and Pathways / immunology
Organ Specificity
Phosphoproteins / classification
Phosphoproteins / genetics*
Phosphoproteins / immunology
Proteomics / methods
SARS-CoV-2 / genetics
SARS-CoV-2 / growth & development
SARS-CoV-2 / immunology
SARS-CoV-2 / pathogenicity*
Signal Transduction
Viral Load

Substances

Phosphoproteins