Airway local endoscopic pharmacological treatment; current applications and future concepts

Paul Zarogoulidis; Christoforos Kosmidis; Konstantinos Sapalidis; Wolfgang Hohenforst-Schmidt; Dimitris Matthaios; Kosmas Tsakiridis; Aimilios Lallas; Chong Bai; Haidong Huang; Christos Arnaoutoglou; Aris Ioannidis; Chrysanthi Sardeli

doi:10.31083/j.fbl2701036

Airway local endoscopic pharmacological treatment; current applications and future concepts

Front Biosci (Landmark Ed). 2022 Jan 19;27(1):36. doi: 10.31083/j.fbl2701036.

Affiliations

¹ 3rd Department of Surgery, "AHEPA" University Hospital, Aristotle University of Thessaloniki, Medical School, 54636 Thessaloniki, Greece.
² Department of Pulmonary Oncology, "Bioclinic" Private Hospital, 54636 Thessaloniki, Greece.
³ Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof'' Clinics, University of Erlangen, 95030 Hof, Germany.
⁴ Department of Oncology, General Hospital of Rhodes, 85100 Rhodes, Greece.
⁵ Department of Thoracic Oncology, "Interbalkan" European Medical Center, 54636 Thessaloniki, Greece.
⁶ First Dermatology Department, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
⁷ Department of Respiratory & Critical Care Medicine, Changhai Hospital, the Second Military Medical University, 200011 Shanghai, China.
⁸ 1st Department of Obstetrics & Gynecology, Papageorgiou Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
⁹ Department of Surgery, "Genesis" Private Clinic, 54636 Thessaloniki, Greece.
¹⁰ Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

PMID: 35090341
DOI: 10.31083/j.fbl2701036

Abstract

Introduction: Local treatment of the airways and lung parenchyma has been used in clinical practice for several years for a variety of diseases.

Methods: A variety of endoscopic tools for local treatment exist, especially for treating malignancies. Using these endoscopic tools, one can administer drugs specifically designed for the airways.

Discussion: This article presents all locally administered treatment options and provides useful insights for future local endoscopically applied treatments.

Keywords: Anti-VEGF; Antibiotics; Bronchoscopy; Cisplatin; Drug; EBUS; Everolimus; Hemostasis; Interferon; Sirolimus; Stents; Taxanes; Zotarolimus.

Publication types

Review

MeSH terms

Drug-Eluting Stents*
Everolimus*
Sirolimus
Treatment Outcome

Substances

Everolimus
Sirolimus