Depression Mediates the Association Between Occupational Complexity and Late-Life Cognition in Hispanics

J Alzheimers Dis Rep. 2021 Dec 21;5(1):881-886. doi: 10.3233/ADR-210040. eCollection 2021.

Abstract

There is a dearth of research in Latin America regarding risk and protective factors affecting older adults' cognition. This study aimed to investigate the factors mediating the association between occupational complexity and late-life cognition and daily function in a sample of Hispanic older adults. Participants (n = 588) aged 65 years and older underwent clinical, functional, and cognitive assessments. Mediation analyses revealed that depressive symptoms mediated the relationship between occupational complexity and cognitive as well as functional outcomes. Results provide evidence that depression may act as a risk factor for worse outcomes, even if older adults had a cognitively demanding occupation.

Keywords: Aging; Latin America; cognitive reserve; executive functions; risk factors.