Exceptional Response to Olaparib and Pembrolizumab for Pancreatic Adenocarcinoma With Germline BRCA1 Mutation and High Tumor Mutation Burden: Case Report and Literature Review

JCO Precis Oncol. 2022 Jan:6:e2100437. doi: 10.1200/PO.21.00437.
No abstract available

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / genetics
  • Aged
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Antineoplastic Agents / therapeutic use*
  • BRCA1 Protein / genetics
  • Germ Cells
  • Humans
  • Male
  • Mutation
  • Pancreatic Neoplasms / drug therapy*
  • Pancreatic Neoplasms / genetics
  • Phthalazines / therapeutic use*
  • Piperazines / therapeutic use*
  • Treatment Outcome
  • Tumor Burden

Substances

  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • BRCA1 Protein
  • BRCA1 protein, human
  • Phthalazines
  • Piperazines
  • pembrolizumab
  • olaparib