FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function

Elena Coccia; Montse Solé; Joan X Comella

doi:10.3389/fcell.2021.826037

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function

Front Cell Dev Biol. 2022 Jan 10:9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021.

Authors

Elena Coccia^{1

2

3}, Montse Solé^{1

2

3}, Joan X Comella^{1

2

3}

Affiliations

¹ Cell Signaling and Apoptosis Group, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.
² Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, Spain.
³ Departament de Bioquímica I Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.

Abstract

Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA-1 as two functional antagonists that modulate non-apoptotic caspase activity in neurons. Their participation in long-term depression and neurite pruning will be described in base of the latest studies performed. In addition, the association of FAIM-L non-apoptotic functions with the neurodegeneration process will be reviewed.

Keywords: Alzheimer's disease; XIAP antagonist; axon remodeling; pruning; synaptic plasticity (LTP/LTD).

Publication types

Review