Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury

Anastasiia O Sosnovtseva; Olga V Stepanova; Aleksei A Stepanenko; Anastasia D Voronova; Andrey V Chadin; Marat P Valikhov; Vladimir P Chekhonin

doi:10.3389/fphar.2021.777628

Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury

Front Pharmacol. 2022 Jan 10:12:777628. doi: 10.3389/fphar.2021.777628. eCollection 2021.

Authors

Anastasiia O Sosnovtseva¹, Olga V Stepanova^{1

2}, Aleksei A Stepanenko^{1

3}, Anastasia D Voronova¹, Andrey V Chadin¹, Marat P Valikhov^{1

2

3}, Vladimir P Chekhonin^{1

3}

Affiliations

¹ Department of Fundamental and Applied Neurobiology, V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, The Ministry of Health of the Russian Federation, Moscow, Russia.
² Department of Neurohumoral and Immunological Research, National Medical Research Center of Cardiology, The Ministry of Health of the Russian Federation, Moscow, Russia.
³ Department of Medical Nanobiotechnology, Institute of Translational Medicine, N.I. Pirogov Russian National Research Medical University, The Ministry of Health of the Russian Federation, Moscow, Russia.

Abstract

The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy is a popular approach for the treatment of such patients. The delivery of therapeutic genes is carried out in a variety of ways, such as direct injection of therapeutic vectors at the site of injury, retrograde delivery of vectors, and ex vivo therapy using various cells. Recombinant adenoviruses are often used as vectors for gene transfer. This review discusses the advantages, limitations and prospects of adenovectors in spinal cord injury therapy.

Keywords: brain-derived neurotrophic factor (BDNF); glial cell derived neurotrophic factor (GDNF); neurotrophin 3 (NT3); recombinant adenovirus; spinal cord injury (SCI).

Publication types

Review