Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations

Miriam Vignando; Dominic Ffytche; Simon J G Lewis; Phil Hyu Lee; Seok Jong Chung; Rimona S Weil; Michele T Hu; Clare E Mackay; Ludovica Griffanti; Delphine Pins; Kathy Dujardin; Renaud Jardri; John-Paul Taylor; Michael Firbank; Grainne McAlonan; Henry K F Mak; Shu Leong Ho; Mitul A Mehta

doi:10.1038/s41467-022-28087-0

Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations

Nat Commun. 2022 Jan 26;13(1):519. doi: 10.1038/s41467-022-28087-0.

Authors

Miriam Vignando¹, Dominic Ffytche², Simon J G Lewis³, Phil Hyu Lee⁴, Seok Jong Chung⁴, Rimona S Weil^{5

6}, Michele T Hu^{7

8}, Clare E Mackay^{7

9}, Ludovica Griffanti^{7

9}, Delphine Pins¹⁰, Kathy Dujardin¹⁰, Renaud Jardri¹⁰, John-Paul Taylor¹¹, Michael Firbank¹¹, Grainne McAlonan¹², Henry K F Mak¹³, Shu Leong Ho¹³, Mitul A Mehta¹⁴

Affiliations

¹ Department of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK. miriam.vignando@kcl.ac.uk.
² Department of Old Age Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.
³ ForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, School of Medical Sciences, University of Sydney, Camperdown, NSW, Australia.
⁴ Yonsei University College of Medicine, Seoul, South Korea.
⁵ Dementia Research Centre, University College London, 8-11 Queen Square, London, WC1M 3BG, UK.
⁶ Wellcome Centre for Neuroimaging, University College London, London, UK.
⁷ Oxford Parkinson's Disease Centre, Oxford, UK.
⁸ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁹ Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK.
¹⁰ Univ. Lille, Inserm, CHU Lille, U1172 - Centre Lille Neuroscience & Cognition, 59000, Lille, France.
¹¹ Newcastle University, Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle Upon Tyne, NE4 5PL, UK.
¹² King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.
¹³ Division of Neurology, Dept of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
¹⁴ Department of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.

Abstract

Parkinson's psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson's disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Bayes Theorem
Brain / diagnostic imaging
Brain Mapping*
Cerebral Cortex
Female
Hallucinations*
Hippocampus
Humans
Male
Middle Aged
Parkinson Disease*
Sensory Receptor Cells*

Abstract

Publication types

MeSH terms

Grants and funding