Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer's disease

Chem Commun (Camb). 2022 Feb 15;58(14):2367-2370. doi: 10.1039/d1cc05792h.

Abstract

Two Keggin polyoxometalates were used as new copper ligands to counteract the effects of CuII(Amyloid-β) interaction. Their ability to remove CuII from CuII(Amyloid-β), to stop CuII(Amyloid-β) induced formation of reactive oxygen species and to restore apo-like self-assembly of CuII(Amyloid-β) was shown.

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / metabolism
  • Anions / chemistry
  • Anions / pharmacology*
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacology*
  • Copper / chemistry
  • Copper / pharmacology*
  • Humans
  • Polyelectrolytes / chemistry
  • Polyelectrolytes / pharmacology*
  • Reactive Oxygen Species / metabolism

Substances

  • Amyloid beta-Peptides
  • Anions
  • Chelating Agents
  • Polyelectrolytes
  • Reactive Oxygen Species
  • polyoxometalate
  • Copper