Rare complication of nadroparin injections: Skin necrosis and heparin-induced thrombocytopenia syndrome

Laura Malinauskiene; Laima Aleksandraviciute; Lina Kryzauskaite; Ilona Savlan

doi:10.1002/ccr3.5297

Rare complication of nadroparin injections: Skin necrosis and heparin-induced thrombocytopenia syndrome

Clin Case Rep. 2022 Jan 18;10(1):e05297. doi: 10.1002/ccr3.5297. eCollection 2022 Jan.

Authors

Laura Malinauskiene^{1

2}, Laima Aleksandraviciute², Lina Kryzauskaite², Ilona Savlan^{2

3}

Affiliations

¹ Vilnius University Institute of Clinical Medicine Clinic of Chest Diseases, Immunology and Allergology Vilnius Lithuania.
² Vilnius University Hospital Santaros Klinikos Vilnius Lithuania.
³ Vilnius University Institute of Clinical Medicine Clinic of Gastroenterology, Nephrourology and Surgery Centre of Hepatology, Gastroenterology and Dietetics Vilnius Lithuania.

Abstract

We described a rare case of nadroparin-induced skin necrosis with thrombocytopenia. LMWH therapy is used in thrombosis prophylaxis, it is important to recognize that skin necrosis can be a part of HIT early in its course and change heparin or LMWH to non-heparin anticoagulants such as direct thrombin III inhibitors or anti-Xa anticoagulants.

Keywords: heparin; heparin‐induced thrombocytopenia syndrome; nadroparin; skin necrosis; thrombocytopenia.

Publication types

Case Reports