In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair

Guodong Liu; Mengjiao Ma; Haoye Meng; Jintao Liu; Yudong Zheng; Jiang Peng; Shuai Wei; Yi Sun; Yansen Wang; Yajie Xie; Junfei Li

doi:10.1016/j.carbpol.2021.119044

In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair

Carbohydr Polym. 2022 Apr 1:281:119044. doi: 10.1016/j.carbpol.2021.119044. Epub 2021 Dec 30.

Authors

Guodong Liu¹, Mengjiao Ma¹, Haoye Meng², Jintao Liu¹, Yudong Zheng³, Jiang Peng⁴, Shuai Wei⁵, Yi Sun¹, Yansen Wang¹, Yajie Xie¹, Junfei Li¹

Affiliations

¹ School of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China.
² School of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China; Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Chinese PLA General Hospital, Beijing, China.
³ School of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China. Electronic address: zhengyudong@mater.ustb.edu.cn.
⁴ Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Chinese PLA General Hospital, Beijing, China. Electronic address: pengjiang301@126.com.
⁵ Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Chinese PLA General Hospital, Beijing, China.

PMID: 35074117
DOI: 10.1016/j.carbpol.2021.119044

Abstract

Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair. Bacterial cellulose (BC) shows excellent biocompatibility and is easy to modified, however it lacks electroactivity. In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs. The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs). The conductivity of BPS was affected by the SNFs doped, and its value was up to 1.8 × 10^-2 S/cm while the sulfonation degree of SNFs reached 93%. Furthermore, nerve conduits made of BPS were implanted in-vivo for 12 weeks, and it great improved the peripheral nerve repair effect. In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.

Keywords: Bacterial cellulose; In-situ self-assembly; Peripheral nerve repair; Poly(3,4-ethylenedioxythiophene); Sulfonated nanofibers doping.

MeSH terms

Bridged Bicyclo Compounds, Heterocyclic
Cellulose
Nanofibers*
Peripheral Nerves
Polymers

Substances

Bridged Bicyclo Compounds, Heterocyclic
Polymers
poly(3,4-ethylene dioxythiophene)
Cellulose