Discovery of Polyoxypregnane Derivatives From Aspidopterys obcordata With Their Potential Antitumor Activity

Hong-Wei Guo; Yun-Gang Tian; Yi-Han Liu; Jia Huang; Jian-Xia Wang; Hua Long; Hua Wei

doi:10.3389/fchem.2021.799911

Discovery of Polyoxypregnane Derivatives From Aspidopterys obcordata With Their Potential Antitumor Activity

Front Chem. 2022 Jan 5:9:799911. doi: 10.3389/fchem.2021.799911. eCollection 2021.

Authors

Hong-Wei Guo¹, Yun-Gang Tian¹, Yi-Han Liu¹, Jia Huang¹, Jian-Xia Wang², Hua Long¹, Hua Wei^{3

4}

Affiliations

¹ College of Biology and Environmental Science, Jishou University, Jishou, China.
² School of Medicine, Jishou University, Jishou, China.
³ School of Pharmaceutical Sciences, Jishou University, Jishou, China.
⁴ Tujia Medicine Research Center in Hunan (Jishou University), Jishou, China.

Abstract

The bioassay-guided phytochemical study of an ethnic medicinal plant Aspidopterys obcorda ta Hemsl. var. obcordata results in the isolation of eight new polyoxypregnane derivatives, named aspidatasides A-H (1-8), along with ten known analogs (9-18). The series polyoxypregnane derivatives were screened for their cytoxic activity against HL-60 cells, and compound 2 showed the highest potency with an IC₅₀ 8.03 μM. Preliminary structure-activity relationship studies displayed that the sugar chain and double bond could notably impact their biological activity.

Keywords: Aspidopterys obcordata; HL-60; ethnic medicine; polyoxypregnane derivatives; structure–activity relationship.