A quasi-2-day wave (Q2DW) event during January-February, 2020, is investigated in terms of its propagation from 96 to 250 km as a function of latitude (10°S to 30°N), its nonlinear interactions with migrating tides to produce 16 and 9.6-h secondary waves (SWs), and the plasma drift and density perturbations that it produces in the topside F-region (590-607 km) between magnetic latitudes 18°S and 18°N. This is accomplished through analysis of coincident Ionospheric Connections Explorer (ICON) measurements of neutral winds, plasma drifts and ion densities, and wind measurements from four low-latitude (±15°) specular meteor radars (SMRs). The Q2DW westward-propagating components that existed during this period consist of zonal wavenumbers s = 2 and s = 3, that is, Q2DW+2 and Q2DW+3 (e.g., He, Chau et al., 2021, https://doi.org/10.1029/93jd00380). SWs in the ICON measurements are inferred from Q2DW+2 and Q2DW+3 characteristics derived from traditional longitude-UT fits that potentially contain aliasing contributions from SWs ("apparent" Q2DWs), from fits to space-based zonal wavenumbers that each reflect the aggregate signature of either Q2DW+2 or Q2DW+3 and its SWs combined ("effective" Q2DWs), and based on information contained in published numerical simulations. The total Q2DW ionospheric responses consists of F-region field-aligned and meridional drifts of order ±25 ms-1 and ±5-7 ms-1, respectively, and total ion density perturbations of order (±10%-25%). It is shown that the SWs can sometimes make substantial contributions to the Q2DW winds, drifts, and plasma densities.