Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Shynggys Sergazy; Anastassiya Vetrova; Ilkay Erdogan Orhan; Fatma Sezer Senol Deniz; Ahmet Kahraman; Jian-Ye Zhang; Mohamad Aljofan

doi:10.2144/fsoa-2021-0109

Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Future Sci OA. 2021 Dec 3;8(2):FSO775. doi: 10.2144/fsoa-2021-0109. eCollection 2022 Feb.

Authors

Shynggys Sergazy¹, Anastassiya Vetrova², Ilkay Erdogan Orhan³, Fatma Sezer Senol Deniz³, Ahmet Kahraman⁴, Jian-Ye Zhang⁵, Mohamad Aljofan²

Affiliations

¹ National Laboratory Astana, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan.
² Department of Biomedical Science, Nazarbayev University School of Medicine, Nur-Sultan, 010000, Kazakhstan.
³ Department of Pharmacognosy, Gazi University, Ankara, 06330, Turkey.
⁴ Department of Biology, Usak University, 64200 Usak, Turkey.
⁵ Key Laboratory of Molecular Target & Clinical Pharmacology & the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, P.R. China.

Abstract

Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively.

Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines.

Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions.

Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.

Keywords: Erodium; Geraniaceae; Geranium; anticancer; antiproliferative; breast cancer; cytotoxicity.