Signal transduction mechanism of exosomes in diabetic complications (Review)

Xueting Li; Shuo Shi; Dehuai Jing; Xinjian Li; Bin Zhang; Qingli Bie

doi:10.3892/etm.2021.11078

Signal transduction mechanism of exosomes in diabetic complications (Review)

Exp Ther Med. 2022 Feb;23(2):155. doi: 10.3892/etm.2021.11078. Epub 2021 Dec 17.

Authors

Xueting Li¹, Shuo Shi², Dehuai Jing³, Xinjian Li⁴, Bin Zhang^{1

2}, Qingli Bie^{1

2}

Affiliations

¹ Department of Clinical Medicine, Jining Medical University, Jining, Shandong 272000, P.R. China.
² Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.
³ Department of Digestive Endoscopy, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.
⁴ Department of Nephrology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.

Abstract

Exosomes are vesicles with a particle size of 30-120 nm that are secreted by cells through exocytosis. The composition of an exosome includes a lipid bilayer and its internal package of biological molecules, such as proteins, ribonucleotides and deoxyribonucleotides. Diabetes is a chronic and refractory disease. The complications induced by high blood glucose have become a major problem in global public health and the pathogenesis of diabetic complications remains to be fully elucidated. In recent years, it has been gradually recognized that exosomes from different cell sources and their related molecules, particularly exosomal proteins and microRNAs, have an important role in the pathogenesis of diabetic complications, allowing for the exploration of the pathogenesis of diabetic complications from a molecular perspective. The present review summarizes the latest studies on exosomes from different cell sources in the pathogenesis of diabetic complications, which may provide novel targets for the prevention and treatment of diabetic complications.

Keywords: complications; diabetic; exosomes; molecule; pathogenesis.

Publication types

Review

Grants and funding

Funding: This study was supported by grants from the National Natural Science Foundation of China (grant nos. 81802446 and 82173371), the Tai Shan Young Scholar Foundation of Shandong Province (grant no. tsqn201909192), the Shandong Provincial Natural Science Foundation (grant nos. ZR2019BH050, ZR2020YQ59 and ZR202103020202) and the Project of Medicine Health and Technology Development Plan of Shandong Province (grant nos. 202003031182 and 202003031183).