Development of the gonadotropin-releasing hormone system

Anne H Duittoz; Paolo E Forni; Paolo Giacobini; Matan Golan; Patrice Mollard; Ariel L Negrón; Sally Radovick; Susan Wray

doi:10.1111/jne.13087

Development of the gonadotropin-releasing hormone system

J Neuroendocrinol. 2022 May;34(5):e13087. doi: 10.1111/jne.13087. Epub 2022 Jan 23.

Authors

Anne H Duittoz¹, Paolo E Forni^{2

3}, Paolo Giacobini⁴, Matan Golan⁵, Patrice Mollard⁶, Ariel L Negrón⁷, Sally Radovick⁷, Susan Wray⁸

Affiliations

¹ CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.
² Department of Biological Sciences, University at Albany, Albany, NY, USA.
³ The RNA Institute, University at Albany, Albany, NY, USA.
⁴ Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172, Inserm, CHU Lille, University of Lille, Lille, France.
⁵ Institute of Animal Sciences, Agricultural Research Organization - Volcani Center, Rishon Letziyon, Israel.
⁶ Institute of Functional Genomics, CNRS, Inserm, Montpellier University, Montpellier, France.
⁷ Clinical and Translational Research, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
⁸ Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD, USA.

Abstract

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

Keywords: GnRH; development; guidance cues; migratory pathway; olfactory ensheathing cells; olfactory placode; synaptic and paracrine signals; terminal nerve; transcription factors.

© 2021 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Female
Gene Expression Regulation
Gonadotropin-Releasing Hormone* / metabolism
Humans
Neurons* / metabolism
Neurosecretory Systems / metabolism
Pregnancy

Substances

Gonadotropin-Releasing Hormone

Abstract

Publication types

MeSH terms

Substances

Grants and funding