A human pluripotent stem cell line KUMi004-A generated from a patient with chronic lymphocytic leukemia

Ji-Hea Kim; Ka-Won Kang; Byung-Hyun Lee; Young Park; Hwa Jung Sung; Byung-Soo Kim

doi:10.1016/j.scr.2022.102668

A human pluripotent stem cell line KUMi004-A generated from a patient with chronic lymphocytic leukemia

Stem Cell Res. 2022 Apr:60:102668. doi: 10.1016/j.scr.2022.102668. Epub 2022 Jan 15.

Authors

Ji-Hea Kim¹, Ka-Won Kang², Byung-Hyun Lee², Young Park², Hwa Jung Sung², Byung-Soo Kim³

Affiliations

¹ Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea.
² Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea.
³ Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea; Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea.

PMID: 35066240
DOI: 10.1016/j.scr.2022.102668

Abstract

Chronic lymphocytic leukemia (CLL) is a type of blood cancer caused by the abnormal accumulation of malignant plasma cells. In this study, we generated CLL iPSCs (KUMi004-a) using the Sendai virus, confirming pluripotency. Also, it can differentiate into three primary germ layers. We expect this cell line could be helpful to understand the pathology of CLL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Humans
Induced Pluripotent Stem Cells* / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
Pluripotent Stem Cells* / metabolism
Sendai virus / genetics