Omicron's message on vaccines: Boosting begets breadth

Duane R Wesemann

doi:10.1016/j.cell.2022.01.006

Omicron's message on vaccines: Boosting begets breadth

Cell. 2022 Feb 3;185(3):411-413. doi: 10.1016/j.cell.2022.01.006. Epub 2022 Jan 14.

Author

Duane R Wesemann¹

Affiliation

¹ Department of Medicine, Division of Allergy and Clinical Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: dwesemann@bwh.harvard.edu.

Abstract

In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune defense-neutralizing antibodies. However, while one- or two-dose vaccine regimens fail to induce anti-Omicron neutralizing antibodies, a homologous third-dose booster rescues neutralization function in a way that highlights the adaptability of immune memory, where recalled immunity extends antibody reach across SARS-CoV-2 variants.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antibodies, Viral
COVID-19 Vaccines
COVID-19*
Humans
SARS-CoV-2
Vaccines*

Omicron's message on vaccines: Boosting begets breadth

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Abstract

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