Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst

Li-Guo Liao; Meng-Meng Song; Jun-Feng Feng; Min Tan; Fan Liu; Zhen-Jiang Qiu; Sheng Zhang; Bang-Jing Li

doi:10.3390/molecules27020580

Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst

Molecules. 2022 Jan 17;27(2):580. doi: 10.3390/molecules27020580.

Authors

Li-Guo Liao^{1

2}, Meng-Meng Song³, Jun-Feng Feng³, Min Tan^{1

2}, Fan Liu^{1

2}, Zhen-Jiang Qiu^{1

2}, Sheng Zhang³, Bang-Jing Li^{1

2}

Affiliations

¹ Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.
³ State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China.

Abstract

An efficient, mild, and green method was developed for the synthesis of indeno[1,2-b]quinoxaline derivatives via o-phenylenediamine (OPD) and 2-indanone derivatives utilizing β-cyclodextrin (β-CD) as the supramolecular catalyst. The reaction can be carried out in water and in a solid state at room temperature. β-CD can also catalyze the reaction of indan-1,2-dione with OPD with a high degree of efficiency. Compared to the reported methods, this procedure is milder, simpler, and less toxic, making it an eco-friendly alternative. In addition, the β-CD can be recovered and reused without the loss of activity.

Keywords: environmentally friendly method; indeno[1,2-b]quinoxalines; reusable catalyst; β-CD.