Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent-Umbrella-Bucket Design

Joseph J Lamb; Michael Stone; Christopher R D'Adamo; Andrey Volkov; Dina Metti; Lucia Aronica; Deanna Minich; Michelle Leary; Monique Class; Malisa Carullo; Jennifer J Ryan; Ilona A Larson; Erik Lundquist; Nikhat Contractor; Brent Eck; Jose M Ordovas; Jeffrey S Bland

doi:10.3390/jpm12010115

Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent-Umbrella-Bucket Design

J Pers Med. 2022 Jan 15;12(1):115. doi: 10.3390/jpm12010115.

Authors

Joseph J Lamb¹, Michael Stone^{1

2

3}, Christopher R D'Adamo^{3

4}, Andrey Volkov⁵, Dina Metti¹, Lucia Aronica^{6

7}, Deanna Minich^{3

8}, Michelle Leary⁹, Monique Class^{3

10}, Malisa Carullo⁶, Jennifer J Ryan¹¹, Ilona A Larson⁶, Erik Lundquist¹², Nikhat Contractor⁶, Brent Eck⁶, Jose M Ordovas¹³, Jeffrey S Bland¹⁴

Affiliations

¹ Personalized Lifestyle Medicine Center, Gig Harbor, WA 98332, USA.
² Office of Personalized Health and Well-Being, Medical College of Georgia, AU/UGA Medical Partnership, Athens, GA 30606, USA.
³ Institute for Functional Medicine, Federal Way, WA 98003, USA.
⁴ Center for Integrative Medicine, University of Maryland, Baltimore, MD 21201, USA.
⁵ Bennet Data Sciences, San Diego, CA 92107, USA.
⁶ Metagenics, Inc., Aliso Viejo, CA 92656, USA.
⁷ Department of Medicine, Stanford Prevention Research Center, Stanford University, Stanford, CA 94305, USA.
⁸ Human Nutrition and Functional Medicine, University of Western States, Portland, OR 97213, USA.
⁹ Vida Integrated Health, Seattle, WA 98112, USA.
¹⁰ The Center for Functional Medicine, Stamford, CT 06905, USA.
¹¹ Helfgott Research Institute, National University of Natural Medicine, Portland, OR 97201, USA.
¹² Personalized Lifestyle Medicine Center, Aliso Viejo, CA 92656, USA.
¹³ Jean Meyer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA 02111, USA.
¹⁴ Personalized Lifestyle Medicine Institute, Bainbridge Island, WA 98110, USA.

Abstract

The working definition of health is often the simple absence of diagnosed disease. This common standard is limiting given that changes in functional health status represent early warning signs of impending health declines. Longitudinal assessment of functional health status may foster prevention of disease occurrence and modify disease progression. The LIFEHOUSE (Lifestyle Intervention and Functional Evaluation-Health Outcomes SurvEy) longitudinal research project explores the impact of personalized lifestyle medicine approaches on functional health determinants. Utilizing an adaptive tent-umbrella-bucket design, the LIFEHOUSE study follows the functional health outcomes of adult participants recruited from a self-insured employee population. Participants were each allocated to the tent of an all-inclusive N-of-one case series. After assessing medical history, nutritional physical exam, baseline functional status (utilizing validated tools to measure metabolic, physical, cognitive, emotional and behavioral functional capacity), serum biomarkers, and genomic and microbiome markers, participants were assigned to applicable umbrellas and buckets. Personalized health programs were developed and implemented using systems biology formalism and functional medicine clinical approaches. The comprehensive database (currently 369 analyzable participants) will yield novel interdisciplinary big-health data and facilitate topological analyses focusing on the interactome among each participant's genomics, microbiome, diet, lifestyle and environment.

Keywords: N-of-one; P4 medicine; behavioral change; chronic disease; diet; functional assessment; functional medicine; genomics; health; methodology; nutrigenomics; nutrition; nutritional supplementation; personalized; personalized lifestyle medicine; precision medicine; quality of life; single-subject analysis.