Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

Dmitry V Korolev; Galina A Shulmeyster; Natalia V Evreinova; Maria S Syrovatkina; Maria S Istomina; Victor N Postnov; Ilia V Aleksandrov; Aleksandr S Krasichkov; Michael M Galagudza

doi:10.3390/ijms23020932

Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

Int J Mol Sci. 2022 Jan 15;23(2):932. doi: 10.3390/ijms23020932.

Authors

Dmitry V Korolev^{1

2}, Galina A Shulmeyster¹, Natalia V Evreinova^{1

3}, Maria S Syrovatkina⁴, Maria S Istomina^{1

4}, Victor N Postnov^{1

5}, Ilia V Aleksandrov¹, Aleksandr S Krasichkov⁶, Michael M Galagudza^{1

7}

Affiliations

¹ Institute of Experimental Medicine, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
² Laboratory of Biophysics of Blood Circulation, Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Street, 197022 Saint Petersburg, Russia.
³ Department of Electrochemical Production, St. Petersburg State Technological Institute Technical University, 26 Moskovsky pr., 198003 Saint Petersburg, Russia.
⁴ Department of Micro- and Nanoelectronics, Saint Petersburg Electrotechnical University "LETI", 5 Professora Popova Street, 197376 Saint Petersburg, Russia.
⁵ Institute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034 Saint Petersburg, Russia.
⁶ Department of Radio Engineering Systems, Saint Petersburg Electrotechnical University "LETI", 5 Professora Popova Street, 197376 Saint Petersburg, Russia.
⁷ Department of Pathophysiology with Clinical Pathophysiology Course, Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Street, 197022 Saint Petersburg, Russia.

Abstract

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS₂/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.

Keywords: chitosan; colloidal quantum dots; indocyanine green; magnetic nanoparticles; multilayer nanoparticles; quinacrine; silica nanoparticles; theranostics.

MeSH terms

Chitosan / chemistry
Early Diagnosis
Fluorescent Dyes / chemistry
Humans
Ischemia / diagnosis*
Ischemia / therapy
Magnetite Nanoparticles / chemistry
Molecular Structure
Nanoparticles
Precision Medicine
Quantum Dots / chemistry*
Quinacrine / chemical synthesis*
Quinacrine / chemistry
Silicon Dioxide / chemistry*
Theranostic Nanomedicine

Substances

Fluorescent Dyes
Magnetite Nanoparticles
Silicon Dioxide
Chitosan
Quinacrine