Human Amniotic Membrane Plug for Chronic or Persistent Macular Holes

Mark D Bamberger; Tina Felfeli; Michael Politis; Efrem D Mandelcorn; Ivan J Galic; John C Chen

doi:10.1016/j.oret.2022.01.006

Human Amniotic Membrane Plug for Chronic or Persistent Macular Holes

Ophthalmol Retina. 2022 May;6(5):431-433. doi: 10.1016/j.oret.2022.01.006. Epub 2022 Jan 17.

Authors

Mark D Bamberger¹, Tina Felfeli², Michael Politis³, Efrem D Mandelcorn⁴, Ivan J Galic⁵, John C Chen⁵

Affiliations

¹ Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address: mark.bamberger@mail.utoronto.ca.
² Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; The Institute of Health Policy, Management and Evaluation (IHPME), Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Toronto Health Economics and Technology Assessment Collaborative, Toronto, Ontario.
³ Division of Retina and Vitreous, Panama Eye Center, Panamá, Panama.
⁴ Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
⁵ Department of Ophthalmology and Visual Sciences, McGill University, Montréal, Québec, Canada.

PMID: 35051667
DOI: 10.1016/j.oret.2022.01.006

Abstract

Purpose: To report on the use of human amniotic membrane for macular holes at 2 Canadian tertiary care centers.

Design: Retrospective cohort study.

Subjects: Twenty-two patients with persistent or chronic macular holes.

Methods: Macular hole surgery was performed by 3 vitreoretinal surgeons.

Main outcome measures: Macular hole closure with complete plugging by human amniotic membrane on spectral-domain OCT.

Results: The closure rate was 91% (20 of 22; median follow-up, 7 months), with no statistically significant visual acuity change overall. Complications included subretinal silicone oil (5%), choroidal neovascularization (5%), atrophy (5%), and cystoid macular edema (9%).

Conclusions: Anatomical success with limited visual recovery was observed.

Keywords: Chronic macular hole; Human amniotic membrane; Macular hole; Persistent macular hole; Refractory macular hole.

MeSH terms

Amnion
Canada
Humans
Retinal Perforations* / diagnosis
Retinal Perforations* / surgery
Retrospective Studies
Vitrectomy