Objective: Hematologic biomarkers that reflect host nutritional and inflammation status have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of preoperative albumin, fibrinogen, prealbumin, albumin/fibrinogen ratio, and prealbumin/fibrinogen ratio (PFR) for the prognosis of patients with glioma.
Methods: X-tile software was used to identify cutoff values of these parameters. Kaplan-Meier survival analysis and univariate and multivariate analyses based on a Cox proportional hazards regression model were used to determine whether these markers were associated with the prognosis of patients with glioma. In addition, the Harrell concordance index with variables was used to evaluate the prognostic accuracy.
Results: The results indicated that PFR (hazard ratio, 2.827; 95% confidence interval, 1.353-6.122; P = 0.006) is the only independent prognostic factor in patients of glioma along with clinicopathologic grade and age. c-index of predicted nomogram including PFR (0.719) for patients with glioma was higher than that without PFR (0.699).
Conclusions: Our findings show that circulating preoperative PFR might be a potential negative independent prognostic biomarker for individuals with glioma.
Keywords: Glioma; Inflammation; Overall survival; Prealbumin/fibrinogen ratio; Prognostic factors.
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