Abstract
Tabernaecorymine A, an 18-normonoterpenoid indole alkaloid with conjugated (E)-3-aminoacrylaldehyde fragment was obtained from the stem bark of Tabernaemontana corymbosa. Its structure was elucidated by extensive spectroscopic data analyses, and further verified by ACD/structure elucidator, electronic circular dichroism (ECD) analyses and density functional theory (DFT) chemical shift predictions. The compound exhibited significant antibacterial bioactivity against Streptococcus dysgalactiae with an MIC value of 3.12 μg/mL, which is better than the plant drug berberine.
Keywords:
Antibacterial activity; Indole alkaloid; Streptococcus dysgalactiae; Tabernaemontana corymbosa.
Copyright © 2022. Published by Elsevier B.V.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Bacillus subtilis / drug effects
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Circular Dichroism
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Escherichia coli / drug effects
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Microbial Sensitivity Tests
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Secologanin Tryptamine Alkaloids / chemistry
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Secologanin Tryptamine Alkaloids / isolation & purification
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Secologanin Tryptamine Alkaloids / pharmacology*
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Staphylococcus aureus / drug effects
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Streptococcus / drug effects
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Tabernaemontana / chemistry*
Substances
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Anti-Bacterial Agents
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Plant Extracts
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Secologanin Tryptamine Alkaloids
Supplementary concepts
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Streptococcus dysgalactiae