Rifamycin mycelial dreg (RMD) is a biological waste, and its residual rifamycin (RIF) is potentially harmful to both the environment and human health. In this work, thermally activated persulfate (PDS) oxidative degradation of RIF in RMD was developed for the first time. The effects of reaction temperature, initial PDS concentration, and pH on RIF degradation in RMD were investigated, and the treatment conditions were optimized using response surface methodology (RSM). The results showed that 90 °C, 50 mg/g PDS, and pH = 5.3 were the optimal pretreatment conditions, and 100% degradation efficiency of RIF (734 mg/kg) was achieved. SEM and FTIR analyses confirmed that the RIF was destroyed and decomposed after the oxidation reaction. The possible degradation pathways of RIF in the thermally activated PDS system were discussed through HPLC/MS and ESR analyses. The intermediate product was identified, and the toxicity of the final product was predicted to be low or nontoxic. In this work, a degradation pathway of RMD was proposed by activating persulfate, which facilitates subsequent resource utilization and provides meaningful guidance for the practical treatment of antibiotic mycelium residue (AMR).
Keywords: Activated persulfate oxidative; Degradation pathway; Response surface methodology; Rifamycin; Rifamycin mycelial dreg.
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