Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans

Ashley Feinsinger; Nader Pouratian; Hamasa Ebadi; Ralph Adolphs; Richard Andersen; Michael S Beauchamp; Edward F Chang; Nathan E Crone; Jennifer L Collinger; Itzhak Fried; Adam Mamelak; Mark Richardson; Ueli Rutishauser; Sameer A Sheth; Nanthia Suthana; Nitin Tandon; Daniel Yoshor; NIH Research Opportunities in Humans Consortium

doi:10.1016/j.neuron.2021.11.011

Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans

Neuron. 2022 Jan 19;110(2):188-194. doi: 10.1016/j.neuron.2021.11.011.

Authors

Ashley Feinsinger¹, Nader Pouratian², Hamasa Ebadi³, Ralph Adolphs⁴, Richard Andersen⁵, Michael S Beauchamp⁶, Edward F Chang⁷, Nathan E Crone⁸, Jennifer L Collinger⁹, Itzhak Fried¹⁰, Adam Mamelak¹¹, Mark Richardson¹², Ueli Rutishauser¹¹, Sameer A Sheth¹³, Nanthia Suthana¹⁴, Nitin Tandon¹⁵, Daniel Yoshor⁶; NIH Research Opportunities in Humans Consortium

Affiliations

¹ Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
² Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: Nader.pouratian@utsouthwestern.edu.
³ Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
⁴ Departments of Psychology and Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA; Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
⁵ Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
⁶ Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
⁷ Department of Neurosurgery, UC San Francisco, San Francisco, CA 94143, USA.
⁸ Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.
⁹ Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15260, USA.
¹⁰ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
¹¹ Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
¹² Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
¹³ Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
¹⁴ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
¹⁵ Department of Neurosurgery, University of Texas Houston, Houston, TX 77030, USA.

Abstract

Leveraging firsthand experience, BRAIN-funded investigators conducting intracranial human neuroscience research propose two fundamental ethical commitments: (1) maintaining the integrity of clinical care and (2) ensuring voluntariness. Principles, practices, and uncertainties related to these commitments are offered for future investigation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Brain
Humans
Morals
Neurosciences*
Research Personnel*
Uncertainty

Abstract

Publication types

MeSH terms

Grants and funding