Sympathetic yet painful: Autonomic innervation drives cluster firing of somatosensory neurons

Matan Geron; Adrien Tassou; Grégory Scherrer

doi:10.1016/j.neuron.2021.12.025

Sympathetic yet painful: Autonomic innervation drives cluster firing of somatosensory neurons

Neuron. 2022 Jan 19;110(2):175-177. doi: 10.1016/j.neuron.2021.12.025.

Authors

Matan Geron¹, Adrien Tassou¹, Grégory Scherrer²

Affiliations

¹ Department of Cell Biology and Physiology, UNC Neuroscience Center, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Department of Cell Biology and Physiology, UNC Neuroscience Center, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; New York Stem Cell Foundation - Robertson Investigator, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: gregory_scherrer@med.unc.edu.

PMID: 35051359
DOI: 10.1016/j.neuron.2021.12.025

Abstract

In this issue of Neuron, Zheng et al. (2021) report synchronized cluster firing of dorsal root ganglion (DRG) neurons that correlates with spontaneous pain in the setting of nerve injury. The authors' findings further suggest that sympathetic sprouting in the DRG plays a key role in this phenomenon.

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MeSH terms

Animals
Ganglia, Spinal* / physiology
Neurons
Pain*
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / physiology