Abstract
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole derivatives target different metabolic pathways of both Gram-positive and Gram-negative bacteria.
Keywords:
Acinetobacter baumannii; ESKAPE pathogens; MRSA; antibacterial; antibiotics; antimicrobials; bacterial resistance; drug-resistant; pyrazole.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Alkyl and Aryl Transferases / antagonists & inhibitors
-
Alkyl and Aryl Transferases / metabolism
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / metabolism
-
Anti-Bacterial Agents / pharmacology*
-
Cell Wall / drug effects
-
Cell Wall / metabolism
-
DNA Gyrase / chemistry
-
DNA Gyrase / metabolism
-
Drug Resistance, Multiple, Bacterial / drug effects*
-
Gram-Negative Bacteria / drug effects
-
Gram-Negative Bacteria / enzymology
-
Gram-Positive Bacteria / drug effects
-
Gram-Positive Bacteria / enzymology
-
Pyrazoles / chemistry*
-
Pyrazoles / metabolism
-
Pyrazoles / pharmacology
-
Tetrahydrofolate Dehydrogenase / chemistry
-
Tetrahydrofolate Dehydrogenase / metabolism
Substances
-
Anti-Bacterial Agents
-
Pyrazoles
-
Tetrahydrofolate Dehydrogenase
-
Alkyl and Aryl Transferases
-
undecaprenyl pyrophosphate synthetase
-
DNA Gyrase