Polyketide Derivatives, Guhypoxylonols A-D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production

Mar Drugs. 2021 Dec 21;20(1):5. doi: 10.3390/md20010005.

Abstract

Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1-4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1-3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1-11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.

Keywords: Aspergillus sp.; anti-inflammatory; guhypoxylonols A–D; mangrove endophytic fungus.

MeSH terms

  • Acanthaceae*
  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Aquatic Organisms
  • Aspergillus*
  • Mice
  • Nitric Oxide / metabolism*
  • Plant Leaves / microbiology
  • Polyketides / chemistry
  • Polyketides / pharmacology*
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Polyketides
  • Nitric Oxide