Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation

Qianmin Gao; Lipeng Wang; Sicheng Wang; Biaotong Huang; Yingying Jing; Jiacan Su

doi:10.3389/fcell.2021.787118

Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation

Front Cell Dev Biol. 2022 Jan 3:9:787118. doi: 10.3389/fcell.2021.787118. eCollection 2021.

Authors

Qianmin Gao^{1

2

3

4}, Lipeng Wang¹, Sicheng Wang⁵, Biaotong Huang^{1

4

6}, Yingying Jing^{1

4}, Jiacan Su⁷

Affiliations

¹ Institute of Translational Medicine, Shanghai University, Shanghai, China.
² School of Medicine, Shanghai University, Shanghai, China.
³ School of Life Sciences, Shanghai University, Shanghai, China.
⁴ Shanghai University Institute of Advanced Interdisciplinary Materials Science, Shanghai, China.
⁵ Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai, China.
⁶ Wenzhou Institute of Shanghai University, Wenzhou, China.
⁷ Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.

Abstract

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem cells, including osteochondral and adipocyte progenitors. Nevertheless, the identification and classification are still controversial, which limits their application. In recent years, by lineage tracing and single-cell sequencing, several new subgroups of BMSCs and their roles in normal physiological and pathological conditions have been clarified. Key regulators and mechanisms controlling the fate of BMSCs are being revealed. Cross-talk among subgroups of bone marrow mesenchymal cells has been demonstrated. In this review, we focus on recent advances in the identification and classification of BMSCs, which provides important implications for clinical applications.

Keywords: BMSC; adipocyte lineage cells; bone marrow mesenchymal stromal cells; multipotent stem cells; skeletal stem cells.

Publication types

Review