The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I-III Colorectal Cancer: A Propensity Score Matching Analysis

Yong Cheng; Yu-Xi Cheng; Xiao-Yu Liu; Bing Kang; Wei Tao; Dong Peng

doi:10.2147/CMAR.S347242

The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I-III Colorectal Cancer: A Propensity Score Matching Analysis

Cancer Manag Res. 2022 Jan 13:14:205-214. doi: 10.2147/CMAR.S347242. eCollection 2022.

Authors

Yong Cheng¹, Yu-Xi Cheng¹, Xiao-Yu Liu¹, Bing Kang², Wei Tao¹, Dong Peng¹

Affiliations

¹ Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
² Department of Clinical Nutrition, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.

Abstract

Purpose: The purpose of the current study was to analyze the effect of type 2 diabetes mellitus (T2DM) on the short-term outcomes and prognosis of stage I-III colorectal cancer (CRC) undergoing primary surgery.

Methods: Patients who underwent primary CRC surgery were retrospectively collected from Jan 2011 to Jan 2020 in a single clinical center. The short-term outcomes and prognosis were compared between T2DM group and non-T2DM group using propensity score matching (PSM) analysis.

Results: A total of 4250 patients were included in this study. There were 521 patients with T2DM and 3729 patients without T2DM. After 1:1 ratio PSM, there were 519 T2DM patients and 519 non-T2DM patients left in this study. No significant difference was found in baseline information after PSM (p>0.05). T2DM had higher overall complications (p=0.033) after PSM in terms of short-term outcomes. As for prognosis, T2DM group had worse overall survival (OS) in all stages (p=0.044), stage I (p=0.009) and stage II (p=0.021) of CRC and T2DM group had worse disease-free survival (DFS) than non-T2DM group in stage I (p=0.008) of CRC before PSM. However, T2DM did not affect the overall survival (OS) or disease-free survival (DFS) on different stages of CRC after PSM (p>0.05). Moreover, T2DM was not an independent predictor of OS or DFS (p>0.05).

Conclusion: T2DM increased overall complications after primary CRC surgery. However, T2DM might not affect OS and DFS of stage I-III CRC patients.

Keywords: colorectal cancer; outcomes; prognosis; type 2 diabetes mellitus.

Grants and funding

This study was supported by Chongqing Key Diseases Research and Application Demonstration Program (Colorectal Cancer Prevention and Treatment Technology Research and Application Demonstration [No. 2019ZX003]).