Model-Informed Precision Dosing of Antibiotics in Osteoarticular Infections

Lingling Liu; Jin Wang; Huan Zhang; Mengli Chen; Yun Cai

doi:10.2147/IDR.S332366

Model-Informed Precision Dosing of Antibiotics in Osteoarticular Infections

Infect Drug Resist. 2022 Jan 11:15:99-110. doi: 10.2147/IDR.S332366. eCollection 2022.

Authors

Lingling Liu¹, Jin Wang¹, Huan Zhang¹, Mengli Chen², Yun Cai¹

Affiliations

¹ Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, People's Republic of China.
² Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, People's Republic of China.

Abstract

As a heterogeneous and wide inflammation, osteoarticular infection (OAI) shows an increasing incidence in recent years. Staphylococcus aureus is the most important pathogen causing OAI. The antibiotic treatment will affect the outcomes of OAI patients, and the drug selection and dosage regimen highly rely on patients' variability, pathogen susceptibility, and drug property like bone permeability. Model-informed precision dosing (MIPD) provides options to describe and quantify the pharmacokinetic (PK) variability of the OAI population using different models, such as the population pharmacokinetic (PPK) model and physiological-based pharmacokinetic (PB/PK) model. In the present review, we highlighted that the MIPD of antibiotics played a critical role in OAI and listed the dose regimen recommended by the model. Collectively, our current study provided a valuable reference for the treatment of patients and improved the safety and efficiency of drug use.

Keywords: PBPK; PPK; antibiotic; dose; osteoarticular infection.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundations of China (81770004 and 82073894) and the Cultivation Project of PLA General Hospital for Distinguished Young Scientists (2020-JQPY-004).