Clinical Characteristics and Prognosis of Allergic Bronchopulmonary Aspergillosis: A Retrospective Cohort Study

Yingying Zeng; Xiaomin Xue; Hui Cai; Guiping Zhu; Mengchan Zhu; Jian Wang; Xixi Song; Yuqing Mo; Xin Gao; Jiaye Zhou; Ling Ye; Meiling Jin

doi:10.2147/JAA.S345427

Clinical Characteristics and Prognosis of Allergic Bronchopulmonary Aspergillosis: A Retrospective Cohort Study

J Asthma Allergy. 2022 Jan 12:15:53-62. doi: 10.2147/JAA.S345427. eCollection 2022.

Authors

Yingying Zeng^{1

2}, Xiaomin Xue^{1

2}, Hui Cai^{1

2}, Guiping Zhu^{1

2}, Mengchan Zhu^{1

2}, Jian Wang^{1

2}, Xixi Song^{1

2}, Yuqing Mo^{1

2}, Xin Gao^{1

2}, Jiaye Zhou³, Ling Ye^{1

2}, Meiling Jin^{1

2}

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
² Department of Allergy, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
³ Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Abstract

Background: The clinical features, treatment, and prognosis of allergic bronchopulmonary aspergillosis (ABPA) are not well-defined.

Objective: We aimed to investigate the clinical characteristics, therapy, and prognosis of ABPA to aid its clinical recognition.

Methods: A total of 232 patients with ABPA were analyzed retrospectively. The characteristics of ABPA in terms of its misdiagnosis, computed tomography classification, therapy, and its relationship with asthma were analyzed, and risk factors for acute exacerbation of ABPA were analyzed based on follow-up data.

Results: Of the 232 ABPA patients, 132 had a history of misdiagnosis. Compared with the misdiagnosed patients, ABPA patients with central bronchiectasis, a high total eosinophil count, and mucus plugs were less likely to be misdiagnosed. Compared with serological ABPA, ABPA with central bronchiectasis was more likely to occur in older people and in patients with mucus plugs, and decreased forced vital capacity and diffusing capacity for carbon monoxide. ABPA patients with asthma were more likely to have bronchiectasis, decreased lung function in 1 s FEV1 and FEV1/FVC, and shorter time to first acute exacerbation compared with ABPA patients without asthma. Patients receiving glucocorticoids plus antifungal therapy had a longer time to first exacerbation than those receiving glucocorticoid therapy alone. Univariate and multivariate analyses revealed that duration of asthma history, duration of misdiagnosis, mucus plugs, and poor pulmonary function were risk factors for acute exacerbation of ABPA.

Conclusion: To our knowledge, this is the largest sample size study of ABPA in China. ABPA patients with a history of asthma and/or central bronchiectasis on high-resolution computed tomography are prone to frequent acute exacerbations. The use of glucocorticoids combined with antifungal drugs can prolong the time to the first acute exacerbation in ABPA patients. Longer durations of asthma history and misdiagnosis, mucus plugs, and poor pulmonary function are risk factors for acute exacerbation of ABPA.

Keywords: allergic bronchopulmonary aspergillosis; central bronchiectasis; diagnosis; follow-up; treatment.

Grants and funding

This work was supported by the Quality control and management system for whole procedure of precision medicine (2017YFC0910003) and Integrated application for standard system of precision medicine (2017YFC0910000), Clinical Research Special Fund of Zhongshan Hospital, Fudan University (2020ZSLC26), Shanghai Shenkang Hospital Development Center Clinical Science and Technology Innovation Project (SHDC2020CR1002A).